Researchers investigating how THC and CBD work together
As research into medical cannabis expands, we’re learning much more about how cannabinoids like THC and CBD interact.
A review of current research published in the journal Medical Hypotheses showed support for the theory that THC and CBD combined increased clinical efficacy while reducing adverse effects, such as intoxication and sedation.
As an example, according to a study published in the Journal of Pain and Symptom Management, 43 per cent of patients who took a THC:CBD extract had a 30 per cent or more improvement in their pain scores – roughly twice the number of patients who had this response in the study’s THC-only and placebo groups.
As part of our commitment to research, Tilray partnered with Toronto’s Hospital for Sick Children to study a low-THC, high-CBD formulation for children with drug-resistant epilepsy. Results from that study were promising, showing a reduction in seizures and improved quality of life for the 19 children who participated.
We’re also providing clinical formulations of THC and CBD to study effects on chemotherapy-induced nausea and vomiting with the University of Sydney in Australia. Researchers will soon begin Phase 3 of their study.
Further research will help us understand how these cannabinoids work together. In the meantime, here is a short list of peer-reviewed articles that look at THC and CBD.
- Oromucosal delta9-tetrahydrocannabinol/cannabidiol for neuropathic pain associated with multiple sclerosis: an uncontrolled, open-label, 2-year extension trial
- Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain
- Cannabidiol-Δ9-tetrahydrocannabinol interactions on acute pain and locomotor activity