Sweet Skunk CBD is a cross of Sweet Skunk and a hybrid strain, Cannatonic. While most modern cannabis strains contain negligible amounts of CBD, strains such as Cannatonic have been bred to contain higher amounts of CBD. The result is a sativa-dominant hybrid with a high content of cannabidiol (CBD) and a lower content of tetrahydrocannabinol (THC).

Many of the qualities of Sweet Skunk CBD derive from its terpene content. Among its top terpenes are: